Local-first molecular design for macOS

Design, verify, and present plasmids without switching tools.

Edit constructs, design primers, review sequencing evidence, simulate cloning, and export clean maps—all on your Mac, with project files kept local.

Download for Mac See the workflow Free Lab Calculators

For macOS 13 or later. Open GenBank, FASTA, and SnapGene .dna files. No RayCrest account is documented as required.

Sequence workspace showing a plasmid selection with codon and protein annotations — Edit the construct with sequence, feature, and protein context visible.

Local project storageWorkspace data stays on your Mac.

Documented interchangeGenBank and FASTA import/export; SnapGene .dna import.

Evidence in contextReview Sanger traces and FASTQ-backed runs beside the construct.

Privacy · Compatibility · Documentation · Support

One connected workflow

Move from construct to verified result.

Keep the same construct in view as each decision becomes the input to the next step.

OpenImport a supported construct.
EditChange the sequence with annotations in context.
PrepareDesign primers or stage an assembly.
VerifyInspect sequencing evidence and mismatches.
PresentExport a clean map or figure.

Walk through every step

Three useful outcomes

Do the work, make the decision, share the result.

Design and edit constructs

Work at base level, keep annotations visible, create primers, and plan documented cloning workflows.

Explore design workflows

Verify experimental evidence

Review Sanger chromatograms or FASTQ-backed evidence and connect mismatches to the construct under review.

Explore validation

Communicate cleanly

Turn the reviewed construct into a focused circular map, linear map, image, vector, or presentation output.

Explore figure export

Product proof

See the input, decision, and output.

Primer Wizard with ranked primer candidates and diagnostic flags — **Input:** an active target region becomes ranked primer candidates.

Sanger chromatogram aligned to a selected mismatch — **Decision:** inspect the chromatogram at the mismatch before accepting the call.

Circular plasmid map prepared as a clean figure — **Output:** a focused plasmid map ready for a report or presentation.

See the complete product walkthrough

Free and Pro

Start with core local work. Add automation when it earns its place.

RayCrest Free

Supported file import, plasmid editing, manual primer design, AB1 viewing, and local project organization.

RayCrest Pro

Automated primer candidates, sequencing-QC interpretation, cloning simulation, protein tools, and publication-ready output.

See pricing · Current local pricing is shown in the App Store.

Know before you download

Compatibility and limitations are part of the decision.

RayCrest MDS supports macOS 13 or later. SnapGene .dna is import-only, native Geneious files are not supported in the standard DNA flow, and Sanger and FASTQ files cannot be mixed in one import selection.

Review compatibility and limitations

Privacy

Project files remain local.

RayCrest documents local workspace storage, no RayCrest-hosted analytics in the app, and no automatic upload of sequence or project data.

Read the privacy policy

Keep your construct and its evidence in one Mac workflow.

Download RayCrest MDS for Mac. RayCrest Pro is $9.99/month.

Download for Mac See pricing